課程資訊
課程名稱
專題討論
Seminar 
開課學期
110-1 
授課對象
生化科技研究所  
授課教師
陳彥榮 
課號
BST7000 
課程識別碼
B22 M0020 
班次
01 
學分
1.0 
全/半年
半年 
必/選修
必修 
上課時間
星期五8,9(15:30~17:20) 
上課地點
共105 
備註
必修4學期。與李昆達、陳俊任、何佳安、林建達合授
限碩士班以上
總人數上限:42人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1101BST7000_01 
課程簡介影片
 
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課程概述

每週由同學選擇期刊論文進行報告,並由老師及同學一起針對該論文進行討論。 

課程目標
一、使同學從閱讀與討論研究論文中獲得新知
二、使同學學習上台演說之能力
三、使同學學習嚴謹思考及對他人研究提出合理批評之能力。 
課程要求
待補 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
待補 
參考書目
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第4週
10/15  An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of
p53-driven progenitor cell differentiation
(施柏任)

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice (許立頎)

 
第5週
10/22  A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression (陳定宇)

An engineered extraplastidial pathway for carotenoid biofortification of leaves (蔣尚伶)

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses (童昱儒) 
第6週
10/29  Carbon Nanocage/Fe3O4/DNA-Based Magnetically Targeted Intracellular Imaging of Telomerase via Catalyzed Hairpin Assembly and Photodynamic–Photothermal Combination Therapy of Tumor Cells (王姿云)

Salvianolic acid B inhalation solution enhances antifibrotic and anticoagulant effects in a rat model of pulmonary fibrosis (仝皓允)

Two Cryptic Self-Resistance Mechanisms in Streptomyces tenebrarius Reveal Insights into the Biosynthesis of Apramycin (賴湘如)
 
第7週
11/05  Importance of OATP1B1 and 1B3 in the Liver Uptake of Luteolin and Its Consequent Glucuronidation Metabolites (陳奕欣)

Delivery of a spheroids-incorporated human dermal fibroblast sheet increases angiogenesis and M2 polarization for wound healing (徐鈺琇)

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase (朱 祈)
 
第8週
11/12  PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis (吳俊毅)

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation (盧學彥)

Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy (高詩涵) 
第9週
11/19  MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer (趙明誠)

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery (鄭凱云)

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance (范宏綦) 
第10週
11/26  Resident cardiac macrophages mediate adaptive myocardial remodeling (陳言亭)

The Skin-Whitening Effects of Ectoine via the Suppression of α-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes (林曉榆)

NIR-Responsive Spatiotemporally Controlled Cyanobacteria Micro- Nanodevice for Intensity-Modulated Chemotherapeutics in Rheumatoid Arthritis (曾咨澂) 
第11週
12/03  Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp (張少筠)

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy (鄭凱安)

Treatment of Rheumatoid Arthritis by Serum Albumin Nanoparticles Coated with Mannose to Target Neutrophils (孫婉慈) 
第12週
12/10  Single-cell transcriptional survey of ileal-anal pouch immune cells from ulcerative
colitis patients (周姿吟)

Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity
(楊辰萱) 
第13週
12/17  Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors (趙珮安)

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration (柯昶宇)